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庄小威团队《细胞》:破解衰老大脑的关键变化
论文标题:Molecular and spatial signatures of mouse brain aging at single-cell resolution
作者:William E. Allen,Timothy R. Blosser,Zuri A. Sullivan,Catherine Dulac,Xiaowei Zhuang
期刊:Cell
发表日期:2022/12/28
大脑细胞
大脑衰老相关机
大脑功能衰退机制
细胞状态
基因表达
细胞空间分布
免疫细胞
2023/01/11 11:40:00
水分充足的人也许更能在衰老的过程中保持健康
论文标题:Middle-age high normal serum sodium as a risk factor for accelerated biological aging, chronic diseases, and premature mortality
作者:Natalia I. Dmitrieva,Alessandro Gagarin,Delong Liu,Colin O. Wu,Manfred Boehm
期刊:EBioMedicine
发表日期:2023/01/02
饮水习惯
饮水健康
慢性疾病
血清钠水平
生物衰老
2023/01/11 11:15:00
一种新的药物输送方法,可用药丸替代注射
论文标题:A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis
作者:Wang, Yuqing,Zhu, Duolong,Ortiz-Velez, Laura C.,Perry, Jacob L.,Pennington, Michael W.,Hyser, Joseph M.,Britton, Robert A.,Beeton, Christine
期刊:PNAS
发表日期:2023/01/03
慢性疾病
给药方式
海葵毒素
罗伊氏乳杆菌
口服药物
给药平台
2023/01/11 10:45:00
DeepMind和谷歌的中期天气预报模型超越顶级气象台
论文标题:GraphCast: Learning skillful medium-range global weather forecasting
作者:Remi Lam,Alvaro Sanchez-Gonzalez,Matthew Willson,Peter Wirnsberger,Meire Fortunato,Alexander Pritzel,Suman Ravuri,Timo Ewalds,Ferran Alet,Zach Eaton-Rosen,Weihua Hu,Alexander Merose,Stephan Hoyer,George Holland,Jacklynn Stott,Oriol Vinyals,Shakir Mohamed,Peter Battaglia
期刊:arXiv
发表日期:2022/12/24
中期天气预报
GraphCast
多层网格
图神经网络
2023/01/11 10:15:00
戴上口罩后,如何优雅地佩戴眼镜?
论文标题:Transparent sunlight-activated antifogging metamaterials
作者:Haechler, Iwan,Ferru, Nicole,Schnoering, Gabriel,Mitridis, Efstratios,Schutzius, Thomas M.,Poulikakos, Dimos
期刊:Nature Nanotechnology
发表日期:2022/12/12
口罩
呼气
眼镜起雾
除霜器
2023/01/11 09:50:35
大脑视觉区域也会参与辨别声音
论文标题:Electrocorticography reveals the dynamics of famous voice responses in human fusiform gyrus
作者:Ariane E. Rhone,Kyle Rupp,Jasmine L. Hect,Emily E. Harford,Daniel Tranel,Matthew A. Howard III,and Taylor J. Abel
期刊:Journal of Neurophysiology
发表日期:2022/12/28
大脑视觉中枢
声音刺激
大脑梭状回
视觉信息
2023/01/11 09:45:00
习惯性查看社交媒体与青少年大脑活动改变有关
论文标题:Association of Habitual Checking Behaviors on Social Media With Longitudinal Functional Brain Development
作者:Maria T. Maza,Kara A. Fox,Seh-Joo Kwon,Jessica E. Flannery,Kristen A. Lindquist,Mitchell J. Prinstein,Eva H. Telzer
期刊:JAMA Pediatrics
发表日期:2023/01/03
青少年神经发育
科技产品
社交媒体
脑科学
社交奖惩
2023/01/11 09:15:00
心脏为什么长在左边?两篇《科学》论文揭秘关键环节
论文标题:Immotile cilia mechanically sense the direction of fluid flow for left-right determination
作者:Takanobu A. Katoh,Toshihiro Omori,Katsutoshi Mizuno,Xiaorei Sai,Katsura Minegishi,Yayoi Ikawa,Hiromi Nishimura,Takeshi Itabashi,Eriko Kajikawa,Sylvain Hiver,Atsuko H. Iwane,Takuji Ishikawa,Yasushi Okada,Takayuki Nishizaka,Hiroshi Hamada
期刊:Science
发表日期:2023/01/06
2023/01/11 08:45:00
超声影像下的生物流体控制机制推动高效节能的流体驱动软阀的开发|JBE封面故事
论文标题:Rapid, Energy-saving Bioinspired Soft Switching Valve Embedded in Snapping Membrane Actuator
作者:Fangzhou Zhao,Yingjie Wang,Sijia Liu,Miao Jin,Luquan Ren,Lei Ren & Chunbao Liu
期刊:Journal of Bionic Engineering
发表日期:2022/09/05
流体驱动器
软体机器人
屈曲膜片驱动器
跳跃屈曲
流体控制
柔性阀
阈值
2023/01/11 07:45:00
新方法用扩展显微镜完整观察细胞内部结构
论文标题:Magnify is a universal molecular anchoring strategy for expansion microscopy
作者:Klimas, Aleksandra,Gallagher, Brendan R.,Wijesekara, Piyumi,Fekir, Sinda,DiBernardo, Emma F.,Cheng, Zhangyu,Stolz, Donna B.,Cambi, Franca,Watkins, Simon C.,Brody, Steven L.,Horani, Amjad,Barth, Alison L.,Moore, Christopher I.,Ren, Xi,Zhao, Yongxin
期刊:Nature Biotechnology
发表日期:2023/01/02
扩展显微镜
生物组织
Magnify
线性膨胀率
细胞内部结构
2023/01/10 14:40:00
40年后美国患有2型糖尿病的青少年可能增加7倍
论文标题:Projections of Type 1 and Type 2 Diabetes Burden in the U.S. Population Aged <20 Years Through 2060: The SEARCH for Diabetes in Youth Study
作者:Thaddäus Tönnies ,Ralph Brinks,Scott Isom,Dana Dabelea,Jasmin Divers,Elizabeth J. Mayer-Davis,Jean M. Lawrence,Catherine Pihoker,Lawrence Dolan,Angela D. Liese,Sharon H. Saydah,Ralph B. D'Agostino,Jr.,Annika Hoyer,Giuseppina Imperatore
期刊:Diabetes Care
发表日期:2022/12/29
糖尿病
青少年
2型糖尿病
2023/01/10 14:10:00
回收复杂废液中的痕量黄金
论文标题:Selective and rapid extraction of trace amount of gold from complex liquids with silver(I)-organic frameworks
作者:Luo, Jie,Luo, Xiao,Xie, Mo,Li, Hao-Zhen,Duan, Haiyan,Zhou, Hou-Gan,Wei, Rong-Jia,Ning, Guo-Hong,Li, Dan
期刊:Nature Communications
发表日期:2022/12/15
金属有机框架材料
暨南材料
痕量黄金
黄金回收
2023/01/10 13:40:00
倒班工作会导致全因痴呆风险增加30%
论文标题:Association of shift work with incident dementia: a community-based cohort study
作者:Huanquan Liao,Dong Pan,Zhenhong Deng,Jingru Jiang,Jinhua Cai,Ying Liu,Baixuan He,Ming Lei,Honghong Li,Yi Li,Yongteng Xu,Yamei Tang
期刊:BMC Medicine
发表日期:2022/12/15
倒班工作
睡眠时间
生物钟节律
代谢紊乱
癌症
心血管疾病
遗传易感性
认知障碍
痴呆
2023/01/10 13:05:00
通往1,080糖的阶梯|《自然-合成》十一月刊
论文标题:Precision copolymerization of CO2 and epoxides enabled by organoboron catalysts
作者:Yang, Guan-Wen,Xu, Cheng-Kai,Xie, Rui,Zhang, Yao-Yao,Lu, Chenjie,Qi, Huan,Yang, Li,Wang, Yuhui,Wu, Guang-Peng
期刊:Nature Synthesis
发表日期:2022/08/25
2023/01/10 11:00:00
AEM:用原位技术阐明MXenes电极的充电机制和耦合结构-力学行为
论文标题:Elucidation of the Charging Mechanisms and the Coupled Structural–Mechanical Behavior of Ti3C2Tx (MXenes) Electrodes by In Situ Techniques
作者:Gil Bergman,Elad Ballas,Qiang Gao,Amey Nimkar,Bar Gavriel,Mikhael D. Levi,Daniel Sharon,Fyodor Malchik,Xuehang Wang,Netanel Shpigel,Daniel Mandler,Doron Aurbach
期刊:Advanced Energy Materials
发表日期:2023/01/03
Ti3C2Tx化合物(MXenes)
充电机制
水基电解质溶液
诱发结构
力学现象
2023/01/10 10:40:00
AM:用于光固化3D打印颗粒增强复合网络的三重融合上转换
论文标题:Triplet Fusion Upconversion for Photocuring 3D Printed Particle-Reinforced Composite Networks
作者:Jitkanya Wong,Shixuan Wei,Rinat Meir,Naroa Sadaba,Nathan A. Ballinger,Elizabeth K. Harmon,Xin Gao,Gokce Altin-Yavuzarslan,Lilo D. Pozzo,Luis M. Campos,Alshakim Nelson
期刊:Advanced Materials
发表日期:2023/01/03
高能光子
聚合物网络
三重态-三重态湮灭上转换
喷墨(DIW)3D打印
水凝胶复合材料
2023/01/10 10:10:00
AM:用于小神经接口的4D印刷柔软可拉伸自折叠袖带电极
论文标题:4D Printed Soft and Stretchable Self-folding Cuff Electrodes for Small-nerve Interfacing
作者:Lukas Hiendlmeier,Francisco Zurita,Jonas Vogel,Fulvia Del Duca,George Al Boustani,Hu Peng,Inola Kopic,Marta Nikić,Tetsuhiko Teshima,Bernhard Wolfrum
期刊:Advanced Materials
发表日期:2023/01/02
周围神经接口
光聚合印刷
聚氨酯
丙烯酸钠水凝胶
2023/01/10 09:40:00
Angew:超微孔MOFs分离乙醇/水的优化筛分效果
论文标题:Optimized Sieving Effect for Ethanol/Water Separation by Ultramicroporous MOFs
作者:Xiaoqing Zheng,Liangji Chen,Hao Zhang,Zizhu Yao,Yisi Yang,Fahui Xiang,Yunbin Li,Shengchang Xiang,Zhangjing Zhang,Banglin Chen
期刊:Angewandte Chemie International Edition
发表日期:2023/01/03
乙醇
可再生能源
痕量水
超微孔MOFs
2023/01/10 09:10:00
JMCB | 张刚课题组发现蛋白磷酸酶与激酶在Bub1/BubR1复合物中空间分隔保证了有丝分裂的正常进行
论文标题:Spatial separation of phosphatase and kinase activity within the Bub complex is required for proper mitosis Lei Wang, Lei Wang The Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266061, China Search for other works by this author on: Oxford Academic PubMed Google Scholar Thomas Kruse, Thomas Kruse Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DK-2200, Denmark Search for other works by this author on: Oxford Academic PubMed Google Scholar Blanca López-Méndez, Blanca López-Méndez Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DK-2200, Denmark Search for other works by this author on: Oxford Academic PubMed Google Scholar Yuqing Zhang, Yuqing Zhang The Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266061, China Search for other works by this author on: Oxford Academic PubMed Google Scholar Chunlin Song, Chunlin Song The Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266061, China Search for other works by this author on: Oxford Academic PubMed Google Scholar Lei Zhu, Lei Zhu The Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266061, China Search for other works by this author on: Oxford Academic PubMed Google Scholar Bing Li, Bing Li The Department of Genetics and Cell Biology, Basic Medical College, Qingdao University, Qingdao 266061, China Search for other works by this author on: Oxford Academic PubMed Google Scholar Jing Fang, Jing Fang The Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266061, China Search for other works by this author on: Oxford Academic PubMed Google Scholar Zhimin Lu, Zhimin Lu Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310029, China Search for other works by this author on: Oxford Academic PubMed Google Scholar Jakob Nilsson, Jakob Nilsson Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DK-2200, Denmark Correspondence to: Jakob Nilsson, E-mail: jakob.nilsson@cpr.ku.dk Search for other works by this author on: Oxford Academic PubMed Google Scholar ... Show more Gang Zhang Gang Zhang The Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao 266061, ChinaNovo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DK-2200, Denmark Correspondence to: Gang Zhang, E-mail: zhanggang_sma@qdu.edu.cn   https://orcid.org/0000-0001-7697-7203 Search for other works by this author on: Oxford Academic PubMed Google Scholar These authors contributed equally to this work. Author Notes Journal of Molecular Cell Biology, mjac062, https://doi.org/10.1093/jmcb/mjac062 Published: 28 November 2022
作者:Wang, Lei,Kruse, Thomas,López-Méndez, Blanca,Zhang, Yuqing,Song, Chunlin,Zhu, Lei,Li, Bing,Fang, Jing,Lu, Zhimin,Nilsson, Jakob,Zhang, Gang
期刊:Journal of Molecular Cell Biology
发表日期:2022/11/28
有丝分裂
真核细胞
遗传物质
蛋白磷酸酶
激酶
酶活性
Bub复合物
2023/01/10 08:39:00
NBT | 利用深度学习模型VAE挖掘药物-多组学数据间的关联
论文标题:Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models
作者:Rosa Lundbye Allesøe,Agnete Troen Lundgaard,Ricardo Hernández Medina,Alejandro Aguayo-Orozco,Joachim Johansen,Jakob Nybo Nissen,Caroline Brorsson,Gianluca Mazzoni,Lili Niu,Jorge Hernansanz Biel,Valentas Brasas,Henry Webel,Michael Eriksen Benros,Anders Gorm Pedersen,Piotr Jaroslaw Chmura,Ulrik Plesner Jacobsen,Andrea Mari,Robert Koivula,Anubh,Ana Vinuela,Juan Fernandez Tajes,Sapna Sharma,Mark Haid,Mun-Gwan Hong,IMI DIRECT Consortium
期刊:Nature Biotechnology
发表日期:2023/01/02
深度学习
MOVE
2型糖尿病
多组学数据
PCA
VAE模型
MOVE t检验
MOVE Bayes
药物
二甲双胍
辛伐他汀
阿托伐他汀
奥美拉唑
2023/01/09 16:00:00
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